Team

Prof. Yiannis Ventikos

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Prof. Yian­nis Ven­tikos — LinkedIn
Prof. Ven­tikos’ research focus­es on trans­port phe­nom­e­na and flu­id mechan­ics, as they are applied to bio­med­ical engi­neer­ing prob­lems, ener­gy, inno­v­a­tive indus­tri­al process­es and bio­com­plex­i­ty. Areas of research include arte­r­i­al haemo­dy­nam­ics and tis­sue remod­el­ling (with an empha­sis on vas­cu­lar dis­eases, like aneurysms), cere­brospinal flu­id dynam­ics, shock-induced bub­ble col­lapse, droplet gen­er­a­tion and depo­si­tion, tar­get­ed drug deliv­ery, swirling flows, chaos, mix­ing and dynam­i­cal sys­tems, organo­gen­e­sis and tis­sue engi­neer­ing, micro- and nano-tech­nolo­gies. Com­pu­ta­tion­al mod­el­ling is at the cen­tre of his research, which spans the spec­trum from fun­da­men­tal to applied. Yian­nis Ven­tikos is the Kennedy Pro­fes­sor of Mechan­i­cal Engi­neer­ing and the Head of the Mechan­i­cal Engi­neer­ing Depart­ment at Uni­ver­si­ty Col­lege Lon­don. He has worked or stud­ied in Greece, France, the USA and Switzer­land. Prof. Ven­tikos has estab­lished the Flu­idics and Bio­com­plex­i­ty Group that cur­rent­ly involves more than twen­ty researchers, most­ly at the doc­tor­al and post­doc­tor­al lev­el. He has pub­lished about 100 papers in peer-reviewed sci­en­tif­ic jour­nals, has con­tributed chap­ters in 5 books, has pre­sent­ed more than 200 papers in inter­na­tion­al con­fer­ences and work­shops and has filed six inter­na­tion­al patents to date. He is the senior aca­d­e­m­ic founder of a spin-out com­pa­ny and con­sults inter­na­tion­al­ly in top­ics of his exper­tise. He has served as a review­er for more than 50 aca­d­e­m­ic jour­nals as well as for text­book and mono­graph pub­lish­ers. He is on the edi­to­r­i­al board of four jour­nals, and on the sci­en­tif­ic and/or organ­is­ing com­mit­tee of numer­ous inter­na­tion­al con­fer­ences and work­shops.

Dr. John Vardakis

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Dr. John Var­dakis — LinkedIn
John is a Research Asso­ciate in Inte­gra­tive Cere­bral Dynam­ics. His main focus is devel­op­ing a com­pu­ta­tion­al frame­work that will aid in the under­stand­ing of cere­bral dis­eases aris­ing from Demen­tia (such as Alzheimer’s Dis­ease, Vas­cu­lar Demen­tia and Nor­mal Pres­sure Hydro­cephalus). He works with­in the VPH-DARE@IT project, which aims to deliv­er the first patient-spe­cif­ic pre­dic­tive mod­els for ear­ly dif­fer­en­tial diag­no­sis of demen­tias and their evo­lu­tion.

The foun­da­tions of the math­e­mat­i­cal mod­el­ling that he works on lies in Mul­ti­ple-Net­work Poro­elas­tic The­o­ry, adapt­ed to patient spe­cif­ic cas­es and sim­u­lat­ed through a com­bi­na­tion of Com­pu­ta­tion­al Flu­id Dynam­ics and the Finite Ele­ment Method. He is work­ing with Dr. Liwei Guo (UCL) and Dr. Dean Chou (Uni­ver­si­ty of Oxford) to devel­op a mod­el­ling plat­form that can han­dle, in an anatom­i­cal­ly accu­rate and patient spe­cif­ic man­ner, the trans­port and inter­play of blood and cere­brospinal flu­id with the neu­ronal and astro­cyt­ic tis­sue that con­sti­tutes the func­tion­ing brain.

Pre­vi­ous: DPhil in Inte­gra­tive Cere­bral Dynam­ics, Uni­ver­si­ty of Oxford, 2010–2014; Cen­tre for Doc­tor­al Train­ing in Health­care Inno­va­tion, Uni­ver­si­ty of Oxford, 2009–2010; BEng in Mechan­i­cal Engi­neer­ing, King’s Col­lege Lon­don, 2005–2008

Dr. Katerina Spranger

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Dr. Kate­ri­na Spranger — LinkedIn
Kate­ri­na Spranger is a post-doc­tor­al researcher in Bio­med­ical Engi­neer­ing at the Uni­ver­si­ty Col­lege Lon­don. She is work­ing on pre­dic­tive com­pu­ta­tions for med­i­cine, in par­tic­u­lar, on patient-spe­cif­ic sim­u­la­tions of sur­gi­cal inter­ven­tions.

Pre­vi­ous: Doc­tor­ate in Bio­med­ical Engi­neer­ing, Uni­ver­si­ty of Oxford, 2014; MSc in Com­put­er Sci­ence, Hum­boldt Uni­ver­si­ty of Berlin, 2009

Dr. Liwei Guo

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Dr. Liwei Guo — LinkedIn
Dr. Guo works in the VPH-DARE@IT project and the main work is to devel­op a three-dimen­sion­al finite ele­ment com­pu­ta­tion­al plat­form of mul­ti­com­part­men­tal poro­elas­tic­i­ty mod­el to sim­u­late flu­id trans­port phe­nom­e­na in the brain, and apply this mod­el to bet­ter under­stand demen­tia. Pri­or to join­ing the FBG group at UCL, Dr. Guo had worked on devel­op­ing frac­ture mod­el for three-dimen­sion­al frac­ture and frag­men­ta­tion sim­u­la­tions based on the finite ele­ment method and the dis­crete ele­ment method, and plas­tic­i­ty mod­el and absorb­ing bound­ary con­di­tion for mod­el­ling dynam­ic prob­lems in trun­cat­ed sol­id mod­els.

Pre­vi­ous: PhD in Com­pu­ta­tion­al Physics, Impe­r­i­al Col­lege Lon­don, 2010 — 2014; MSc in Engi­neer­ing Mechan­ics, Chi­nese Acad­e­my of Sci­ences, 2007 — 2010; BSc in Civ­il Engi­neer­ing, Chi­na Agri­cul­tur­al Uni­ver­si­ty, 2003 — 2007

Dr. Tom Peach

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Dr. Tom Peach — LinkedIn
Tom is a post-doc­tor­al researcher work­ing in the field of mod­el­ling cere­bral blood flow. His work focus­es in par­tic­u­lar on the design of nov­el min­i­mal­ly inva­sive devices and the patient-spe­cif­ic treat­ment of cere­bral aneurysms. He is cur­rent­ly col­lab­o­rat­ing with the Min­i­mal­ly Inva­sive New Tech­nolo­gies Group (Weill Cor­nell Med­ical Col­lege) and the Oxford Neu­rovas­cu­lar and Neu­ro­ra­di­ol­o­gy Research Unit (Uni­ver­si­ty of Oxford).
His oth­er research inter­ests include fold­ing and self-deploy­ing struc­tures, flow sta­bil­i­ty, and both in-vit­ro and ani­mal mod­els.

Pre­vi­ous: DPhil in Bio­med­ical Engi­neer­ing, Uni­ver­si­ty of Oxford, 2011–2015; MEng and MA, Uni­ver­si­ty of Cam­bridge, 2006–2010

Daniel Baeriswyl

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Daniel Baeriswyl — Phd Stu­dent — LinkedIn
Daniel stud­ies how shear stress trig­gers the acti­va­tion and nuclear translo­ca­tion of NF-κB in vas­cu­lar endothe­lial cells. NF-κB is a key pro­mot­er of inflam­ma­to­ry respons­es and plays a piv­otal role in cell growth, sur­vival and apop­to­sis. Hence a rela­tion­ship between NF-κB and shear stress would con­tribute to a bet­ter under­stand­ing of car­dio­vas­cu­lar dis­eases. We inves­ti­gate the effect of tem­po­ral and spa­tial shear stress gra­di­ents on the acti­va­tion of NF-κB with in-vit­ro exper­i­ments in col­lab­o­ra­tion with Prof. Rob Krams from Impe­r­i­al Col­lege Lon­don and cre­ate a numer­i­cal mod­el to pre­dict inflam­ma­to­ry respons­es in com­plex ves­sel geome­tries.

Pre­vi­ous: Vis­it­ing Researcher, Depart­ment of Aero­nau­tics, Cal­i­for­nia Insti­tute of Tech­nol­o­gy, US, 2011; MSc in Mechan­i­cal Engi­neer­ing, ETH Zurich, Switzer­land, 2010 — 2012; BSc in Mechan­i­cal Engi­neer­ing, ETH Zurich, Switzer­land, 2005 — 2009

Anjana Kothandaraman

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Anjana Kothandara­man — PhD Stu­dent — LinkedIn
Exper­i­men­tal and Com­pu­ta­tion­al Analy­sis of Bub­ble Gen­er­a­tion Com­bin­ing Microflu­idics and Elec­tro­hy­dro­dy­nam­ics: This project involves com­bin­ing Microflu­idics and Elec­tro­hy­dro­dy­nam­ics to pre­pare monodis­perse microbub­bles for diag­nos­tic appli­ca­tions. Sole­ly using microflu­idic devices to manip­u­late microbub­ble size expe­ri­ences lim­i­ta­tions espe­cial­ly with very vis­cous solu­tions, hence cap­i­tal­is­ing on the well under­stood con­cept of bub­ble res­o­nance, var­i­ous types of elec­tric fields are inves­ti­gat­ed to facil­i­tate bub­ble break-up. A com­pu­ta­tion­al mod­el will be cre­at­ed to sim­u­late the entire exper­i­men­tal set-up and enable bet­ter under­stand­ing of  flu­id mechan­ics of the flow and the elec­tro­hy­dro­dy­nam­ic inter­ac­tions

Pre­vi­ous: MSc in Bio­engi­neer­ing and Bio­med­ical Engi­neer­ing, Brunel Uni­ver­si­ty, 2012–2013; BEng in Com­put­er Engi­neer­ing, Brunel Uni­ver­si­ty, 2009 — 2012

Xiang Pan

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Xiang Pan — PhD Stu­dent
Prepa­ra­tion of microbub­ble: Numer­i­cal and exper­i­men­tal study of a nov­el microflu­idic K-junc­tion: The project aims to analyse the effect of bound­ary con­di­tions such as liquid/gas flow rate, gas inlet pres­sure and phys­i­cal prop­er­ties of liq­uid and gas espe­cial­ly den­si­ty, sur­face ten­sion and vis­cos­i­ty, on the mix­ture and gen­er­a­tion process of monodis­perse microbub­bles in a cir­cu­lar cross sec­tion nov­el microflu­idic K-junc­tion device via numer­i­cal sim­u­la­tion and exper­i­ment. It is also focused on the the­o­ry of the bubble’s break off mech­a­nism with mul­ti­phase flu­id inside of the K-junc­tion via numer­i­cal sim­u­la­tion thus improve­ment and cor­re­la­tions in the exper­i­ment will be devel­oped based on the sim­u­la­tion results.

Pre­vi­ous: BEng in Mechan­i­cal Engi­neer­ing, Uni­ver­si­ty of Hert­ford­shire, 2011–2013; BEng in Mechan­i­cal Design, Man­u­fac­tur­ing and Automa­tion, Henan Uni­ver­si­ty of Sci­ence and Tech­nol­o­gy, 2009–2011

Babatunde Aramide

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Babatunde Aramide — PhD Stu­dent — LinkedIn
heo­ret­i­cal Frame­work and Com­pu­ta­tion Flu­id Dynam­ics Mod­el­ling of the Elec­tro­spin­ning Process for Fibre For­ma­tion: The research focus pri­mar­i­ly on under­stand­ing the under­ly­ing physics in the Elec­tro­spin­ning Process and Mod­el­ling the process Com­pu­ta­tion­al­ly, here­by pro­vid­ing a plat­form to under­stand inter­ac­tion of the para­me­ters for the fibre for­ma­tion. Also, it is aimed at study­ing  role of the poly­mer solution’s rhe­ol­o­gy in the nanofi­bre for­ma­tion. The applic­a­bil­i­ty of the mod­el for Axi­al elec­tro­spin­ning and Cell elec­tro­spin­ning will also be explored. This work is Co-Super­vised by Dr Suwan Jayas­inghe of UCL.

Pre­vi­ous: Msc. Mechan­i­cal Engi­neer­ing, Uni­ver­si­ty Col­lege Lon­don, UK, 2013–2014; BTech. Mechan­i­cal Engi­neer­ing, Ladoke Akin­to­la Uni­ver­si­ty of Tech­nol­o­gy,  Nige­ria, 2005–2010

Hannah Safi

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Han­nah Safi — PhD Stu­dent
Blood Flow and the Devel­op­ment of Aneurysms: Nov­el Inves­tiga­tive Meth­ods: The com­plex inter­ac­tion between a deformable body and a sur­round­ing flu­id such as in the case of a deform­ing atri­al wall and blood flow is referred to as flu­id struc­ture inter­ac­tion (FSI). Exper­i­men­tal stud­ies involv­ing aneurysms have typ­i­cal­ly only employed flu­id flow mea­sure­ments with rigid mod­els. This PhD will present a nov­el tech­nique where simul­ta­ne­ous flu­id flow and atri­al wall defor­ma­tion mea­sure­ments will be car­ried out using the meth­ods of Par­ti­cle Image Velocime­try and Dig­i­tal Image Cor­re­la­tion respec­tive­ly. This work is there­fore pre­sent­ing a nov­el com­bined mea­sure­ment tech­nique that has the poten­tial to yield insight into the under­stand­ing of the patho­phys­i­ol­o­gy of aneurys­mal ini­ti­a­tion, growth and even­tu­al rup­ture.

Pre­vi­ous: BSc in Applied Physics, Uni­ver­si­ty of Portsmouth, 2011–2014

Xizhuo Jiang

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Xizhuo Jiang — PhD Stu­dent — Research Gate
Effect of gly­co­ca­lyx on mem­brane chan­nels in kid­ney: Mol­e­c­u­lar Dynam­ics Sim­u­la­tions: This research focus­es on the effect of gly­co­ca­lyx on the per­me­abil­i­ty of water and solutes dur­ing trans­mem­brane trans­ports. Mol­e­c­u­lar Dynam­ics (MD) sim­u­la­tions will be con­duct­ed to com­pare the per­me­abil­i­ty of key mem­brane chan­nels with nor­mal and abnor­mal gly­co­ca­lyx under the con­di­tion of flu­id shear stress, there­by explain­ing for the dys­func­tion of kid­ney. The work is expect­ed to shed light on the caus­es of some kid­ney fail­ure and renal dis­eases. This research is also super­vised by Prof. K. H. Luo of Mechan­i­cal Engi­neer­ing, UCL.

Pre­vi­ous: Researcher in Cen­ter for Com­bus­tion and Ener­gy, Tsinghua Uni­ver­si­ty, Chi­na, 2014–2015; MSc in Ther­mal Engi­neer­ing, Tsinghua Uni­ver­si­ty, Chi­na, 2012–2014; BEng in Ther­mal Engi­neer­ing, Tsinghua Uni­ver­si­ty, Chi­na, 2006–2010

Nikolaos Bempedelis

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Niko­laos Bem­pedelis — PhD Stu­dent
Sim­u­la­tions of shock­wave-bub­bles inter­ac­tions: The project aims to inves­ti­gate com­pu­ta­tion­al­ly the inter­ac­tions of shock waves with mul­ti­ple gas-filled bub­bles in a liq­uid medi­um. A front-track­ing approach is to be employed, which allows for an explic­it track­ing and accu­rate rep­re­sen­ta­tion of the gas-liq­uid inter­face. The (three-dimen­sion­al) sim­u­la­tions will be car­ried out using a freely-dis­trib­uted and well-val­i­dat­ed code, devel­oped at Stony Brook Uni­ver­si­ty. A “library” of results will be con­struct­ed and an attempt to form empir­i­cal laws that describe the col­lapse process and the inter­ac­tion between the gas bub­bles will be car­ried out.

Pre­vi­ous: Research Assis­tant, DMAE, ONERA Toulouse, France, 2016; MSc in Aero­space Mechan­ics and Avion­ics, ISAE-SUPAERO, France, 2014–2016; Research Assis­tant, Lab­o­ra­to­ry of Aero­dy­nam­ics, NTUA, Greece, 2014; Diplo­ma in Mechan­i­cal Engi­neer­ing, NTUA, Greece 2008–2013