We develop and utilise novel computational methodologies to explore problems in energy generation, storage and the environment. Central to this topic are advanced methods capable of solving thermofluids governing equations in extreme conditions.
Involved people: Nikolaos Bempedelis
We investigate processes connected with blood flow, thrombosis, wall remodelling, mechanotransduction, endothelium biomechanics as well as methodologies to invent, design and optimise devices and procedures that treat vascular disease using implants, in a minimally invasive setting.
HUVECs expressing GFP-RelA exposed to 100ng/mL TNF-alpha. Imaged with a confocal microscope. Check out the nucleus before and after 30 mins. pic.twitter.com/vYM8PZIbRl
— FBG (@FBG_UCL) November 10, 2016
We develop methodologies that address the challenge of scale disparity and complexity, to model the pathophysiology of entire organs. Central to this effort is a novel modelling paradigm – Multicompartmental Poroelasticity – that allows for capturing microscale (cellular/molecular) processes, and for embedding those seamlessly in the biomechanics of the entire organ. The human brain, and associated diseases like dementia and hydrocephalus, has been an organ that we have investigated using this modelling approach.